Postdoctoral Researcher in Oxygen and Vitamin Metabolism (Jain Lab) at Arc Institute
Job Description
Arc Institute’s Jain Lab is hiring postdoctoral researchers in oxygen and vitamin metabolism. The lab studies how what we breathe and eat shapes metabolism and disease, and its finding that chronic hypoxia can treat mitochondrial disease is now in clinical trials.
At a glance
- Role: Postdoctoral Researcher, Jain Lab
- Where: Palo Alto, California, USA
- Pay: Minimum base salary US$80,000 a year, set by months of postdoctoral experience
- Level: PhD in metabolism, physiology, molecular biology, biochemistry, genomics or related
- Apply: open until filled (re-checked 12 October 2026)
About the Jain Lab postdoc
- Find new functions for enzymes or cofactors (vitamins)
- Contribute to the molecular understanding of how the body senses key metabolites
- Develop new therapeutic strategies based on nutrients or oxygen
- Collaborate with other postdocs and students on how enzymes and metabolites interact
- Publish and present the lab’s work at journals, conferences, lab meetings and Arc-wide events
The lab asks how cells and organisms sense oxygen and vitamin levels, how the body adapts when they change, how mismatched supply and demand drives disease, and whether “turning the oxygen and vitamin dials” could become therapy. Its tools include CRISPR screens, metabolomics, classical biochemistry and molecular biology, and animal physiology.
Arc postdocs are encouraged to lead ambitious, independent projects and can draw on shared platforms for genomics, single-cell technologies, synthetic biology, computation and experimental model systems across Arc and its partner universities.
What Arc Institute is looking for
- A PhD in metabolism, animal physiology, molecular biology, biochemistry, genomics or a related field
- Excellent written and spoken communication
- The ability to design new research directions with input from the PI, and eagerness to learn new techniques
- Enthusiasm for problems with translational impact
Pay and location
Arc lists a minimum base salary of US$80,000 a year for this postdoc. The actual base salary depends on how many months of relevant postdoctoral experience the successful candidate has, and Arc says it is not negotiable. The role is based at Arc’s Palo Alto headquarters.
How to apply
Apply through the official Arc Institute job posting. Arc Institute’s posting does not give a closing date, so the role is open until filled; ResearchJobs.in will re-check this listing on 12 October 2026. Check the posting for location and work-authorisation details before you apply.
See all our postdoctoral fellowships, or browse more research jobs on ResearchJobs.in.
Hiring institution: Arc Institute
Official advertisement: job-boards.greenhouse.io
How to prepare for this application
- Hypoxia biology: revise oxygen sensing (for example the HIF pathway) and mitochondrial disease basics.
- Cofactors: think about how a vitamin-dependent enzyme could be discovered with a CRISPR screen and metabolomics.
- Physiology: be ready to discuss animal models you have used or would use.
- Translation: propose how a finding could become a nutrient-based therapy.
- Read the lab's papers: especially the work on hypoxia as a therapy for mitochondrial disease.
About Arc Institute
Arc Institute is an independent nonprofit research organisation working at the interface of artificial intelligence and biology. Founded in 2021 and based in Palo Alto, it partners with Stanford University, UC Berkeley and UC San Francisco, and gives its scientists long-term philanthropic funding with industry-like resources. Its two institute-wide initiatives are building a virtual cell model and mapping the causes of Alzheimer's disease, and more than 300 people work at its headquarters.
