Postdoc in Single-Cell Proteomics for Drug Delivery Research at Karolinska Institutet

Job Description

Prof. Samir El Andaloussi’s lab in the Department of Laboratory Medicine at Karolinska Institutet is hiring a postdoc in mass-spectrometry-based proteomics. The lab develops ways to deliver proteins, RNA drugs and gene therapies into cells, using engineered extracellular vesicles (EVs) and lipid nanoparticles (LNPs). You will use quantitative, single-cell and phosphoproteomics to study where these delivery systems go, how they act and what they do to cells and tissues.

At a glance

• Position: Postdoctoral researcher (1 post), full time, temporary
• Where: Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Flemingsberg (Huddinge)
• PI: Prof. Samir El Andaloussi, samir.el-andaloussi@ki.se
• Reference: STÖD 2-3565/2026
• Apply by: 23 September 2026
• Apply: 23 September 2026

About the proteomics postdoc

• Characterise drug delivery technologies for ASOs, siRNAs, proteins and other nucleic-acid drugs, including EVs and LNPs
• Run quantitative proteomics end to end: sample preparation, LC-MS/MS and computational data analysis
• Use single-cell proteomics to study cell-specific responses to drug delivery
• Use phosphoproteomics to map signalling pathways and mechanisms of action
• Apply these methods in disease-relevant cell and tissue models

What to include in your application

KI asks for documents in English or Swedish: a complete CV (with the date and title of your thesis, previous academic positions and distinctions), a complete list of publications, and a summary of your current work of no more than one page. Applications are submitted through KI’s Varbi recruitment system.

What Karolinska Institutet is looking for

• A PhD awarded no more than seven years before the last date of postdoc employment (extendable in special circumstances)
• A solid background in mass-spectrometry-based proteomics
• Practical experience in proteomic sample preparation, LC-MS/MS and quantitative proteomics data analysis
• Excellent spoken and written English

Nice to have

• Single-cell proteomics and phosphoproteomics experience (particularly meritorious)
• Proteomics work on drug responses, mechanisms of action, cell signalling or drug delivery
• Developing and optimising proteomics workflows and analysing complex biological samples

Pay and location

The post is a full-time temporary employment with a monthly salary. KI sets salaries individually under its collective agreements; the advert gives no figure.

How to apply

Apply through the official Karolinska Institutet page. The closing date is 23 September 2026.

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