JRF in Protein NMR for Atherosclerosis Drug Targets (FMO3 and TMA Lyases) at IIT Roorkee
Job Description
IIT Roorkee’s Department of Biosciences and Bioengineering is hiring a Junior Research Fellow to study protein-ligand complexes by NMR spectroscopy, on a GSBTM-sponsored project led by Prof. Krishna Mohan Poluri to develop inhibitors against FMO3 and TMA lyases, enzymes involved in the progression of atherosclerosis. Parts of the notice are handwritten.
At a glance
- Position: Junior Research Fellow (1 post)
- Project: Development of inhibitors against FMO3 and TMA lyases involved in the progression of atherosclerosis
- Sponsor (as written): GSBTM
- Pay: Rs 31,000 plus HRA per month
- Duration: One year
- Walk-in interview: 21 September 2026, 9:30 AM, BSBE, IIT Roorkee
Gut microbes use TMA lyase enzymes to turn nutrients such as choline and carnitine into trimethylamine (TMA), which the liver enzyme FMO3 converts into TMAO, a molecule linked to atherosclerosis. Blocking either step is being explored as a way to lower cardiovascular risk, and NMR spectroscopy shows exactly how candidate inhibitors bind to these proteins.
About the JRF role
- NMR spectroscopy analysis of protein-ligand complexes
- Contribute to developing inhibitors against FMO3 and TMA lyases
The selected candidate may get an opportunity for Ph.D. admission. On the notice, a printed pay figure is struck out and replaced by hand with Rs 31,000 plus HRA per month.
Eligibility
- M.Sc. in Life Sciences or Biotechnology, or M.Tech in Biotechnology
- GATE qualified
- Experience with protein NMR is preferred
Open to Indian nationals only. Among equally qualified candidates, SC/ST candidates will be preferred. No TA/DA is paid for attending the interview.
Pay and duration
- Rs 31,000 plus HRA per month
- Duration: one year
How to apply
This is a walk-in interview. Bring an application on plain paper with a detailed CV (degrees and certificates in chronological order), details of any research or other experience, attested copies of your certificates and the originals for verification. You can also send your application to the PI in advance by email (krishna.poluri@bt.iitr.ac.in) or by post.
Key dates
- Walk-in interview: 21 September 2026, 9:30 AM, Department of Biosciences and Bioengineering, IIT Roorkee
Please read the official IIT Roorkee advertisement (PDF) before applying, and browse more JRF positions on ResearchJobs.in.
Hiring institution: Indian Institute of Technology Roorkee
Official advertisement: iitr.ac.in
How to prepare for this application
- NMR basics: revise 1D and 2D protein NMR (such as HSQC), chemical shift perturbation and what it tells you about binding.
- Protein work: expression, purification and isotope labelling of proteins for NMR.
- The biology: read about the TMA and TMAO pathway and its link to heart disease.
- Binding measurements: how dissociation constants are estimated from titration data.
- GATE: have your scorecard ready; it is required.
About IIT Roorkee
IIT Roorkee traces its roots to Roorkee College, set up in 1847 and renamed the Thomason College of Civil Engineering in 1854. It became the country's first technical university in 1948, as the University of Roorkee, and was converted into an Indian Institute of Technology on 21 September 2001, when it was recognised as an Institution of National Importance.
